On November 12, 2024, Reactor 6 at the Givaudan Sense Colour (formerly D.D. Williamson) caramel coloring facility in Louisville, Kentucky ruptured catastrophically. A runaway thermal decomposition reaction of sugar ingredients — invert sugar and corn syrup — generated enormous pressure that overwhelmed the vessel. The explosion killed two workers, seriously injured two others, and ejected a section of the pressure vessel beyond the fence line into a neighboring residential unit.
The facility produced caramel coloring by heating sugar ingredients under high temperature and pressure. What engineers and management did not know — because they had never tested it — was that these sugars decompose exothermically at elevated temperatures, generating CO₂ gas and heat that can rapidly overpressurize a closed vessel. No calorimetry had ever been performed on the process materials. No PSM program existed. Reactor 6 had no pressure relief system sized for the decomposition scenario.
The CSB's final report (released May 27, 2026) identified a complete absence of Process Safety Management as the systemic cause. Eight recommendations were issued, all targeting reactive chemistry characterization, PSM system development, adequate relief design, and safe operating limit alarm systems.
This incident traced to breakdowns across 5 PSM elements (PSI · PHA · MI · SOP · EP). Each represents a documented gap that process safety documentation and consulting can close before a similar event occurs at your facility.